Formation of complete and incomplete antibodies in rabbits immunized with sheep's red cells

Abstract

A parallel determination of incomplete and complete antibodies in rabbits immunized with different doses of sheep's red cells showed that the decrease in titers of complete antibodies takes place more rapidly than that of incomplete. Complete 7S-antibodies appear in the blood of animals immunized with large doses of red cells or after repeated injections of small doses of the antigen. Incomplete 7S-antibodies can be detected in the blood of rabbits after primary immunization with both large and small doses of sheep's red cells. The titers of incomplete hemagglutinins in the reaction with native and trypsinized red cells are almost identical. The titers of complete hemagglutinins, on the other hand, are higher in the reaction with trypsinized red cells than in the reaction with native cells and they are similar in value to the titers of incomplete antibodies.