Formation of certified reference materials and standard measurement guides for development of traceable measurements of mass fractions and sizes of nanoparticles in different media and biological matrixes on the basis of gamma-ray and optical spectroscopy

Abstract

Metrological assurance has been developed and formed for a promising technique for measuring the mass fraction and number concentration of nanoparticles containing silver or zinc in different media, including those of a biological nature, i.e., the gamma-ray spectroscopy of neutron-activated samples along with dynamic light scattering. The advantage of this complex measurement technique over other approaches to analytically controlling nanomaterials is discussed. The certified reference materials and standard guides developed in order to ensure the uniformity and traceability of measurements are described. The technique is tested in experiments on the kinetics of accumulation and removal of silver nanoparticles in different organs and excrement of laboratory rats.