Abstract
The first committed step in the tetrapyrrole biosynthetic pathway, leading to chlorophylls, hemes and bilins, is the formation of 6-aminolevulinic acid (ALA). In plants, algae and some bacteria, ALA is formed from glutamate by a sequence of reactions which has been localized in the plastids in plants and eukaryotic algae (1). Soluble extracts from a variety of plants and algae are capable of converting glutamate to ALA when supplemented with ATP, Mg2+, and NADPH (2–5).
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