Abstract

Accumulating data suggest that dietary supplementation of fish oils rich in eicosapentaenoic acid (EPA) and eicosapentaenoic acid (DHA) increases susceptibility of isolated low density lipoprotein (LDL) to peroxidation1–4. Oxidative modication of LDL may contribute to tissue damage through cytotoxic reactions with endothelial cells or through further reactions to generate “modified” LDL which is selectively accummulated by “scavenger” receptors5. Therefore, concern has been raised with respect to the high intake of EPA and DHA in numerous trials in the prevention of disease as well as encouragement to self medication by the health food industry.KeywordsEicosapentaenoic AcidFree Radical AttackStudy Lipid PeroxidationCopper Catalysed OxidationHarvey Research InstituteThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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