Abstract
Several epidemiological and experimental studies have shown that asbestos- and man-made mineral fibres (MMMFs) are carcinogenic, but the underlying molecular mechanisms have not yet been resolved. Recent studies indicate that asbestos and MMMFs can induce the formation of reactive oxygen species. Furthermore, it is considered probable that oxygen radicals are invonlved in mutagenesis and carcinogenesis (Cerutti, 1985), since many exogenous chemicals, that are mutagens and carcinogens, produce vast amounts of oxygen radicals. Although the molecular mechamisms for hydroxyl radical-induced carcinogenesis is not known, reactive oxygen metabolites attack the DNA- molecule producing many different types of damage, including DNA strand breaks and base hydroxylations. Therefore, it is not unlikely that hydroxyl radical-induced DNA damage, e.g. formation of 8-hydroxydeoxyguanosine (8-OH-dG) represents a critical event in mutagenesis and carcinogenesis.
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