Abstract
Dimethyl sulfoxide (DMSO) is widely utilized compound in biomedical and technological applications. Predominantly, it is used for biomembranes opening during a drug delivery procedure. The mechanism of DMSO membrane treatment is influenced by DMSO interactions with Ca2+ as well as with water presence. In this study we investigate Ca2+ interactions with DMSO in an aqueous environment using electrospray ionization mass spectrometry supported by density functional calculations. The number of DMSO ligands in [Ca(DMSO)x]2+ depends on the conditions during the electrospray and ion-transfer process. At capillary temperatures lower than 120°C the complexes with a high number of DMSO are preferentially transferred to the gas phase (e.g. [Ca(DMSO)6]2+). With increasing temperature the number of DMSO ligands decreases while they are replaced with water molecules. Both the experiment and the calculations show that the bonding energy of DMSO to Ca2+ is strongly influenced by the presence of water. The calculations also demonstrate that the bonding of DMSO to Ca2+ is rather strong; the Ca2+-DMSO bonding energy was calculated to be two times higher than the Ca-H2O bonding energy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
