Abstract
To characterize the microchannels created in hairless rat skin by microneedles and investigate their closure following exposure to different occlusive conditions. Maltose microneedles were characterized by scanning electron microscopy. The microchannels created and their closure when exposed to different conditions was investigated using a variety of techniques. Microscopic imaging indicates a pyramidal geometry of maltose microneedles with an average length of 559 ± 14μm and tip radius of 4μm. Upon insertion into skin, they created microchannels with an average surface diameter of 60μm and an average depth of 160 ± 20μm as observed by histological sectioning and confocal microscopy. Skin recovers its barrier function within 3-4hrs, and microchannels closed within 15hrs of poration when exposed to environment. However, when occluded, the microchannels remained open for up to 72hrs in vivo, as observed by calcein imaging, transepidermal water loss measurements and methylene blue staining. Maltose microneedles penetrated the stratum corneum barrier and created microchannels in skin which completely close within 15hrs after poration. However, under occluded conditions, barrier recovery can be delayed for up to 72hrs in vivo.
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