Formal total synthesis of altohyrtin C (spongistatin 2). Part 2: Construction of fully elaborated ABCD and EF fragments

Takeshi Terauchi,Ippei Sato,Kyoko Kimijima,Wataru Shoji,Masataka Morita,Masaya Nakata,Gouichirou Hayashi,Taisaku Tanaka,Takashi Tsunoda,Taro Terauchi,Tomoharu Tsukada,Yasuhiro Nakamura,Naoki Kanoh

doi:10.1016/j.tetlet.2003.08.083

Formal total synthesis of altohyrtin C (spongistatin 2). Part 2: Construction of fully elaborated ABCD and EF fragments

Takeshi Terauchi, Ippei Sato + Show 11 more

https://doi.org/10.1016/j.tetlet.2003.08.083

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Journal: Tetrahedron Letters	Publication Date: Oct 1, 2003
Citations: 32

Affiliation: Keio University

#EF Fragments #Formal Synthesis + Show 4 more

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Abstract

Abstract Coupling of the C1C14 (AB) crotylstannane with the C15C28 (CD) aldehyde followed by stereochemical arrangements gave the C1C28 (ABCD) fragment of altohyrtin C. The C29C44 (EF) fragment was also prepared. The syntheses of these two fragments, both of which were identical with those prepared by the Smith group, constitute a formal total synthesis of altohyrtin C.

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