Abstract
The most commonly recognized form of hereditary diabetes insipidus is that transmitted through an autosomal gene as a simple dominant, as described by Weil (1884), Lauritzen (1893), Ellermann (1939) and others. In 1945 I described three families which showed that it could also be inherited as a sex-linked recessive. In 1945 the largest family contained 21 unquestionable cases of diabetes insipidus (23 in 1953) and the smallest 3 cases. I personally tested 11 of these men with the antidiuretic hormone (ADH) and found that all of them reacted or at any rate were never definitely refractory to the hormone. This is in agreement with earlier findings on autosomally inherited diabetes insipidus, and also with my own observations in a number of cases in which the disorder was inherited in this manner. The medium-sized family contained 8 men with unequivocal diabetes insipidus. Three of the men were tested with ADH and
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