Forensic features and genetic structure at insertion/deletion polymorphisms of Chinese Han with other 31 Chinese ethnic groups

Abstract

Insertion/deletion polymorphisms (InDels) have been used in population genetics, anthropology, archaeology and forensic. Chinese Han population with 1.3 billion people is the largest homogeneous ethnicity in the world. Here, we reanalyzed the allele frequency distributions and forensic parameters of 30 InDels included in Qiagen Investigator DIPplex kit in a Meta-Han Chinese population and then explored the genetic affinity between Meta-Han group and other 31 Chinese ethnic populations belonging to different administrative divisions using Fst genetic distances, multidimensional scaling (MDS), phylogenetic analysis and Structure. The values of CPD and CPE in Han Chinese are 0.999999999984 and 0.9879 respectively, which indicating this panel is informative in Han Chinese and can be used for forensic individual identification, while just be served as a supplementary tool for parentage testing. The comprehensive population comparisons reveal that Han Chinese have the genetically closer relationship with Fujian She and Zunyi Miao. Findings from pairwise genetic distances, MDS and phylogenetic analysis demonstrate that genetic affinity is related to ethnic origin, geographical distribution and linguistic background. STRUCTURE analysis indicates that the same language or ethnic origin populations or geographically adjacent groups have similar ancestry composition.