Abstract
Short tandem repeat (STR) markers on the X chromosome (XSTRs) have found an important niche in forensic DNA testing, principally in kinship and paternity testing where complex relationships using autosomal STR markers provide limited statistical support (e.g., paternal half-sisters). XSTR multiplexes have been developed and are commercially available. Like autosomal STRs, XSTRs can be analyzed in the laboratory without the need for specialized equipment. However, the interpretation of XSTR results and the determination of the strength of evidence is different than autosomal STRs as the XSTR markers are clustered into linkage groups. We discuss some of the unique properties of XSTR testing, and provide some areas of future applications and research.
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