Abstract
1110 The purpose was to determine whether patients with insulin-dependent diabetes mellitus (IDDM) have reduced vasodilatory capacity as determined by mercury-in-silastic strain gauge plethysmography. Measurements of forearm blood flow were taken in 15 IDDM (Age:29±6; Ht:180±4cm; Wt:87±12kg) and 15 controls (Age:25±6yr; Ht:180±4cm; Wt:83±13kg) in a supine position, at rest (RBF), following 5 min of ischemia (ISC), and following 3 min of repetitive contractions (RC) during ISC(RISC). ISC was induced by inflating a cuff to 240 mmHg on the upper arm. RC were performed using a hand dynamometer (Intensity=25% MVC, contraction frequency=1/4s). Postprandial blood glucose and HbgA1c for IDDM were 175±63mg/dL and 8.2±1.3%, respectively suggesting borderline hyperglycemia. Despite this glycemic state the results indicate no significant differences in RBF and forearm vascular responsiveness to ISC and RISC between IDDM and controls matched for age and exercise capacity. TableTable
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