Fordyce Spot Symptoms and Treatment: An Updated Review

Abstract

Fordyce granules occur frequently, and most people consider their quality to be a typical variation of the oral mucosa. The multiple yellow granules that primarily show up in the lower lip are a clear sign of Fordyce granules, a type of benign ectopic sebaceous gland. Most often, it affects adult males. Although it has been proven that such glands have been there since the time you were born, their tubes flow directly onto the skin’s surface. When they develop as a consequence of steroid hormones released by the gonadal and adrenal glands, they are not visible until pubescence. Around 70 to 80% of the population are adults. A comprehensive analysis of the literature search was conducted. A number of databases have been searched using the common terms “sebaceous glands,” “oral mucosa”, “Fordyce patches”, “Fordyce granules,” “Fordyce spots,” and “Fordyce glands” using Science Direct, Springer PubMed and Google Scholar as search engines. We have focused on the reviews and research papers published between 2001 and 2024. Although they are a common occurrence in the body, they are not connected to any disease or condition and are not contagious. They can be treated with isotretinoin, picrolimus, 5-aminolaevulinic acid, CO2 laser therapy, and micropuncture therapy. Hormonal fluctuations, greasy sebaceous glands, and hyperlipidemia bring on Fordyce spots. This is a rare but serious condition that causes lesions on the skin’s surface along with pain and discomfort in the affected part of the body.