Abstract
<p>The Forced Swim Test (FST) is a rodent behavioral paradigm utilized for assessment of potential antidepressant-like medications. In this model the mice are put in a plexiglas tank. The tank is loaded with water and the behavior of the mice to escape the tank is scored. The behavioral parameter scored in this test is called immobility, resembling a behavioral state of misery, as seen in human depression.</p><p> </p><p><strong>VIDEO CLIPS</strong></p><p><a href="https://www.youtube.com/v/smWevgzklrQ">Pre-experiment:</a> 50 sec</p><p><a href="https://www.youtube.com/v/W-BSm7wZEM8">Experiment:</a> 7 min 12 sec</p>
Highlights
The Forced Swim Test (FST) is a rodent behavioral paradigm utilized for assessment of potential antidepressant-like medications
The length of immobility time is scored during the testing period and decrease in the length of time of immobility during this test is termed as antidepressant activity (Liao et al, 2013; Aslam and Sultana, 2015)
Forced Swimming Test (FST) is one of the most commonly utilized models for assessing potential antidepressant compounds. This model is often used in rodents to evaluate antidepressant-like activity by assessing the decrease in immobility time (Rodrigues et al, 2002; Suzuki et al, 2001)
Summary
The Forced Swim Test (FST) is a rodent behavioral paradigm utilized for assessment of potential antidepressant-like medications. In this model the mice are put in a Plexiglas tank. The tank is loaded with water and the behavior of the mice to escape the tank is scored. The mice try to come out of the water and this behavior is known as “mobility”.
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