FORCED DEGRADATION STUDIES OF VINCAMINE BY HPTLC

Abstract

Vincamine is an alkaloid with vasodilator properties. Vinpocetine, a semi-synthetic vincamine derivative alkaloid, is used to treat cerebrovascular diseases like stroke and dementia. Being an important molecule, the current research work examines the forced degradation studies of vincamine using planar chromatography, HPTLC using stability studies parameters such as degradation by acid and base hydrolysis, oxidative stress degradation, hydrolytic induced degradation, photolytic degradation and dry heat degradation. The compound was found to be stable to oxidative stress, but significant degradation occurred under acid hydrolysis, base hydrolysis, water hydrolysis, and to a lesser extent, under thermal stress and photolytic stress. The percentage recovery of vincamine was found to be lower in acidinduced degradation (31.8 %), and base-induced degradation (8.2 %) than in UV-induced degradation (94.9 %) and dry heat-induced degradation (93.1 %). In pharmaceutical research and development, forced degradation experiments are essential for predicting long-term stability.