Abstract
Infectious Disease Development of a broad flu vaccine has been hampered by a lack of insight into protective mechanisms of seasonal vaccines across individuals. Avey et al. performed a systems-level analysis on multiple influenza vaccination cohorts spanning distinct geographical locations and vaccination seasons. They identified prevaccination predictive transcriptional signatures of influenza vaccination responses. They then validated nine genes and three gene cohorts that were associated with the magnitude of antibody response in an independent cohort. However, these signatures were specific to young patients and had an inverse correlation in older individuals. These data may help to predict antibody response to influenza vaccination and shed light on the distinct mechanisms governing immune responses in young and old people. Sci. Immunol. 2 , eaal4656 (2017).
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