Abstract
Aim: to determine the mechanism of food sensitization in children with chronic Opisthorchis felineus invasion. Patients and methods: during the epidemiological study the groups of patients (7–10 years) with chronic opisthorchiasis (n =237) and children without chronic opisthorchiasis (n =496) were formed. The investigation included interviewing of parents / guardians, measurement of total IgE, specific IgE to food allergens and component-resolved diagnostic, real-time PCR in stool samples. Results: the chronic opisthorchiasis invasion in children is associated with reduced risk of food sensitization, compared with non-infected group (9,7 vs 16,94%, OR =0,53; 95% CI 0,31–0,88; p =0,01). Opisthorchiasis of high intensity negatively correlated with increased level of specific IgE to food allergens in serum (OR =0,46; 95% CI 0,24–0,91; p =0,023). The association between level of total IgE and intensity of opisthorchiasis combinated with food sensitization was found. The sensitization to allergens class I (cyp c1, cor a11, gal d2, pru p3) is more prevalent in patients with opisthorchiasis, in uninfected children the sensitization to bet v1-homologues (mal d1, pru p1, cor a1, ara h8) is most common. Conclusions: the epidemiological data on the effect of the Opisthorchis felineus invasion on mechanisms of food sensitization in children were obtained.
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