Food intake inhibition elicited by intraportal glucose and adrenaline in dogs on a 22 hour-fasting/2 hour feeding schedule

Abstract

The intraportal injections of saline or 1.2 g/kg glucose had no effect on the food intake of dogs being fed for 2 hr daily in their home cages with a mixture of Purina chow and canned meat. However, intraportal injections of 2 to 3.6 g/kg produced a complete supression of feeding lasting more than 2 hr, or at least a substantial reduction of food intake. The same doses injected intrajugularly had no effect. Adrenaline injected intraperitoneally (100–200 μg/kg) or intraportally (100 μg/kg) elicited a complete inhibition of feeding lasting more than two hours, or a substantial reduction, while the same doses injected intramuscularly or intrajugularly had no effect. All these results indicate that glucose and adrenaline produce food intake inhibition via receptors located in the portohepatic region.