Abstract
The effects of jejunoileal bypass (JIB) surgery on food intake and body weight were investigated in obese and lean rats. Obese rats lost considerably more weight after bypass surgery than did lean animals, and reduced food intake was the primary cause of their weight loss. Both the degree and type of obesity influenced the anorexia and weight reduction produced by JIB. Hypothalamic obesity was completely reversed by JIB, but genetic obesity (fatty rat) and spontaneous obesity were only partially blocked. However, JIB performed prior to hypothalamic surgery attenuated, but did not prevent the development of hyperphagia and obesity. The weight loss produced by JIB was fully recovered following reconnection of the intestinal tract. The feeding and weight reducing effects of JIB appear to result, at least in part, from the visceral malaise produced by the surgery, and from feeding inhibitory signals produced by overstimulation of the lower ileum.
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