Published Version
Open DOI LinkAbstract
Currently approved food additives, including color additives, have a long history of safe use in human consumables. Many food additives are added to increase the flavor or other sensory appeal of food items and have typically been viewed as enhancing the experience of eating or drinking. Research on the impact of food color additives (FCAs) upon neurobehavior, especially focusing on hyperactive behavioral symptoms in children and adolescents, began in the mid-1970s in the United States (US) with animal and human studies.
Highlights
Food additives, including Food color additive (FCA), have been regulated since at least the thirteenth century [1]
A particular focus of research has been associated with consumption of FCAs and potential for negative neurobehavioral effects in children diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) or symp
A second search was conducted for the date range of January 01, 2017 [42] to 22 July 2019 intended to identify any human intervention or challenge studies associated with FCAs that were not captured in the literature reviews or meta-analyses
Read more 
Summary
Introduction
Food additives, including FCAs, have been regulated since at least the thirteenth century [1]. Modern FCAs are used by food product developers to indicate palatability, or tastiness, of food and beverage products. Colors are added to ensure an even, consistent appearance and to replace intrinsic color lost during processing, and create visual cues that match flavoring cues, all to help food and beverage products meet the expectations of consumers. One specific concern associated with certain FCAs has been the potential for the induction of or worsening of negative neurobehavioral effects, hyperactivity behaviors in children [2,3]. A particular focus of research has been associated with consumption of FCAs and potential for negative neurobehavioral effects in children diagnosed with Attention-Deficit/Hyperactivity Disorder (ADHD) or symp-
Methods
Results
Conclusion
Sign-in/Register to view highlights & summary Full Text
Open DOI Link Sign-in/Register to access full text options Topics from this Paper
Behavioral Symptoms In Children- History Of Safe Use
- Food Color Additives
- United States Food
- Food Additives + Show 5 more
Create a personalized feed of these topics
Get StartedTalk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
Secret Ingredients: Who Knows What's in Your Food? 
Relevant
Not Relevant
Environmental Health Perspectives
Apr 1, 2013
RelevantNot Relevant The safety and regulatory status of food, drug and cosmetics colour additives exempt from certification RelevantNot Relevant
- Food and Chemical Toxicology
- Jun 1, 1995
RelevantNot Relevant History of safe use as applied to the safety assessment of novel foods and foods derived from genetically modified organisms RelevantNot Relevant
- Food and Chemical Toxicology
- Dec 1, 2007
RelevantNot Relevant Kobo’s surface treatment for cosmetic pigments makes them hydrophobic RelevantNot Relevant
- Focus on Pigments
- Sep 1, 2002
RelevantNot Relevant The role of the concept of “history of safe use” in the safety assessment of novel foods and novel food ingredients. Opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) RelevantNot Relevant
- Molecular Nutrition & Food Research
- May 2, 2011
RelevantNot Relevant Sea Buckthorn Leaves and the Novel Food Evaluation RelevantNot Relevant
- Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.
- Jun 27, 2017
RelevantNot Relevant Food and Drug Administration proposed testing guidelines for developmental toxicity studies. Revision Committee. FDA Guidelines for Developmental Toxicity and Reproduction, Food and Drug Administration. RelevantNot Relevant
- Regulatory toxicology and pharmacology : RTP
- Aug 1, 1999
RelevantNot Relevant Yacon, a new source of prebiotic oligosaccharides with a history of safe use RelevantNot Relevant
- Trends in Food Science & Technology
- Jan 1, 2011
RelevantNot Relevant Children and adolescents living with HIV positive parents: Emotional and behavioural problems RelevantNot Relevant
- Vulnerable Children and Youth Studies
- Jul 1, 2006
RelevantNot Relevant Assessing the History of Safe Use of Guayusa RelevantNot Relevant
- Journal of Food and Nutrition Research
- Aug 12, 2018
RelevantNot Relevant Analysis of Benzonatate Overdoses Among Adults and Children from 1969–2010 by the United States Food and Drug Administration RelevantNot Relevant
- Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
- Jan 1, 2013
RelevantNot RelevantREAD MORE FROMJournal of Pediatric Neurology and Neuroscience
Treatment of COVID Encephalitis in Pediatric Patient with IVIG 
Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Dec 31, 2022
RelevantNot Relevant Treatment of Bi-Allelic PRRT-2 Mutation Associated Ataxia and Paroxysmal Dyskinesia Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Dec 31, 2022
RelevantNot Relevant Reversible Cerebral Vasoconstriction Syndrome following Exchange Transfusion and Steroids in a Child with Sickle Cell Disease: A Case Report Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Dec 31, 2022
RelevantNot Relevant Unusual Diagnosis and Extended Management of Chronic Inflammatory Demyelinating Polyneuropathy in an Unimmunized Patient Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Dec 31, 2022
RelevantNot Relevant It's a Bit Crowded in Here: Examining Pressure Reactivity in Craniocerebral Disproportion Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Jun 30, 2022
RelevantNot Relevant A Novel PPP2CA Gene Variant Presenting with Dystonia and Progressive Brain Atrophy Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Jan 31, 2022
RelevantNot Relevant Focal Electrographic Hints in Epileptic Spasms Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Jan 21, 2022
RelevantNot Relevant CD59 Deficiency in Two Bahraini Children: Clinical Profile and Outcome Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Dec 31, 2021
RelevantNot Relevant Febrile Coronavirus and Autism Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Dec 31, 2021
RelevantNot Relevant Childhood Epileptic Encephalopathy in Sokoto, Northwestern Nigeria Open AccessRelevantNot Relevant
Open Access- Journal of Pediatric Neurology and Neuroscience
- Dec 31, 2021
RelevantNot Relevant