Food antigen sensitization in genetically-susceptible mice is influenced by fecal IgA, antigen absorption, and gut microbiome composition

Abstract

Despite the prevalence and severe nature of food allergy, mechanisms underlying sensitization remain to be elucidated. Previously, we demonstrated CC027/GeniUnc mice, but not C3H/HeJ mice, develop peanut allergy after oral exposure to peanut in the absence of a Th2-skewing adjuvant. Here we investigated factors contributing to sensitization following oral exposure to peanut, walnut, milk, or egg.