Food allergy and abdominal nain-predominant functional gastrointestinal disorder

Abstract

Abdominal pain-predominant functional gastrointestinal disorder(FGID) plays an important role in inducing functional chronic abdominal pain in children.It has been confirmed that early-life adverse events,such as neonatal maternal separation,infection,pain stimulation,acute stress,will result in the onset of the FGID in childhood and even in adult.The food allergy,particularly milk allergy,is the most common anaphylactic disease in infants,which is the main reason leading to the onset symptom of the FGID in later life.It has practical significance that the early detection and timely treatment of food allergy will prevent and treat the symptoms of FGID.This review summarizes the correlation and the progress of prevention and treatment between food allergy and FGID. Key words: Food allergy; Abdominal pain-predominant functional gastrointestinal disorder; Mast cell; Visceral hyperalgesia