Abstract
Keratomycosis is a rare sight-threatening infection of the cornea. Predisposing factors in its pathogenesis are corneal trauma, mostly of plant origin, contact lenses, and overuse of topical corticosteroids. We report a case of a 44-year-old woman, with no ophthalmologic history, who developed severe keratitis 7 days after beginning topical therapy with a corticosteroid and antibiotic. Microbiological analysis revealed Fusarium oxysporum keratitis. Despite aggressive antifungal therapy with Voriconazole and Amphotericin B, she required a penetrating keratoplasty for impending corneal perforation. A second keratoplasty was performed because of corneal-transplant rejection after 6 months. There was no recurrence of Fusarium infection.
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