Follow-up study onexecutive function of frontal lobe in schizophrenics with and without homicide behaviors

Abstract

：Objective To explore thecharacteristics of executive function and the changes of executive function inschizophrenics with and without homicide behaviors during follow-up.Methods Twenty-twoschizophrenics with homicide behaviors (homicide group)and twenty-one schizophrenicswithout homicide behaviors (without-homicide group) were examined by Wisconsin CardSorting Test(WCST),and followed up 3 months.All patients'clinical symptoms were evaluatedby positive and negative symptom scale(PANSS)at the same time.Re-suits (1)At thebaseline,homicide group showed higher score in complete lst category(R1st)thanwithout-homicide group((28.64±32.73)vs(11.71±8.10),P=0.027)and no difference on otherindex.(2)No difference on WCST in homicide group between at the baseline and atthree-month treatment (P>0.05).Without-homicide group at the baseline showed higherscore in conceptual level responses than that of at three-menth treatment((46.80±27.04)vs.(65.02±21.32),P=0.048).(3)Homicidegroup at three-month treatment showed lower scores in positive scale,generalpsychopathology scale,PANSS total,thought disorder,activation,paranoid,aggressive thanthat of at the baseline(P<0.05).Without-hemicide group at three-month treatment showedlower scores in positive scale,negative scale,general psychopathology scale,PANSStotal,thought disorder,activation,aggressive than that of at the haseline(P<0.01).(4)Atthe baseline,there was no correlation between WCST and PANSS in homicide group,only R1stscore correlated with activation positively in without-homicide group(P<0.05).Atthree-month treatment, homicide group showed the score of failure to maintain setnegatively correlated with negative scale,PANSS total, andaggressive(P<0.05).Conclusions Schizophrenics with homicide and without-homicidebehaviors show executive function deficits.Homicide group shows more deficits inabstraction capacity than without-homicide group.