Follow-up of asthma control and quality of life after discontinuation of omalizumab in severe asthmatic patients

Abstract

Results The mean age was 53.5±9.5 and duration of asthma was 21.2±11.2 years. Serum total IgE level was 380.3±196 IU/mL. Mean duration of omalizumab treatment was 54.6±15 months. Loss of asthma control was documented in 10/16 patients (62.5%). The mean time to the first moderate to severe asthma exacerbation after discontinuation was 2.68±2.2 months. No correlation was found between time to loss of control and duration of omalizumab treatment. The mean score of ACT in the time of discontinuation of omalizumab decreased from 22.13±1.2 to 21.06±1.5 at 3th months (p=0.0001) and to 19.3 ±2.0 at 12th months of discontinuation (p=0.005). The number of exacerbation within the last 12 months increased from 1.3±0.9 to 3.4±3.2 (p=0.006), and the number of hospitalization increased from 0.12±0.26 to 0.6±0.9 within 12 months of discontinuation. The mean score of AQLQ decreased from 4.17±0.8 to 3.26±0.7 at 12th months of discontinuation (p=0.0001).