Abstract
Purpose Kawasaki Disease is the most common vasculitis of childhood, and carries considerable morbidity with risk of development of coronary artery aneurysms. Serological predictors of the development of coronary artery aneurysms have not yet been found. FSTL-1 is a proinflammatory protein which is produced by mesenchymal tissue, including cardiac myocytes, and has been found to be elevated in inflammatory disorders such as Juvenile Idiopathic Arthri tis. The current study was designed to determine if plasma levels of FSTL-1 correlate with the development of Kawasaki Disease and development of coronary artery aneurysms. Methods
Highlights
Kawasaki Disease is the most common vasculitis of childhood, and carries considerable morbidity with risk of development of coronary artery aneurysms
Follistatin like protein (FSTL-1) levels are elevated in acute Kawasaki Disease and may differentiate between patients with and without aneurysm formation
FSTL-1 levels were significantly elevated in patients with acute Kawasaki Disease as compared to age-matched controls
Summary
Follistatin like protein (FSTL-1) levels are elevated in acute Kawasaki Disease and may differentiate between patients with and without aneurysm formation. From 2011 Pediatric Rheumatology Symposium sponsored by the American College of Rheumatology Miami, FL, USA. Purpose Kawasaki Disease is the most common vasculitis of childhood, and carries considerable morbidity with risk of development of coronary artery aneurysms. Serological predictors of the development of coronary artery aneurysms have not yet been found. FSTL-1 is a proinflammatory protein which is produced by mesenchymal tissue, including cardiac myocytes, and has been found to be elevated in inflammatory disorders such as Juvenile Idiopathic Arthritis. The current study was designed to determine if plasma levels of FSTL-1 correlate with the development of Kawasaki Disease and development of coronary artery aneurysms
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