Abstract
Follicular variant of papillary thyroid carcinoma (FVPTC) presented as an autonomous functioning thyroid nodule is a rare finding. We reported a case of 70-year-old male presented with complaints of palpitation and heat intolerance. On palpation, we found a thyroid nodule of 4 cm in the left lobe. Thyroid function tests revealed hyperthyroidism, and radioactive iodine uptake scan (RAIU) showed increased uptake in the left lobe consistent with a hot nodule. The probability of the benign nature of hyperfunctioning thyroid nodule discussed but patient requested further workup to rule out any remote possibility of thyroid cancer. We performed a fine needle aspiration (FNA), and the cytological examination suggested the possibility of thyroid carcinoma. The patient underwent total thyroidectomy, and histological examination revealed follicular architecture with nuclear features of papillary carcinoma in 1 cm area of the thyroid nodule. In the review of the literature, we identified the following seven cases of FVPTC arising within a hyperfunctioning thyroid nodule.
Highlights
A thyroid nodule is a common problem in clinical practice
Thyroid function tests revealed hyperthyroidism, and radioactive iodine uptake scan (RAIU) showed increased uptake in the left lobe consistent with a hot nodule
In the review of the literature, we identified the following seven cases of Follicular variant of papillary thyroid carcinoma (FVPTC) arising within a hyperfunctioning thyroid nodule
Summary
A thyroid nodule is a common problem in clinical practice. Thyroid nodule >1 cm in any diameter required a serum thyroid stimulating hormone (TSH) level. We present a case of a follicular variant of papillary thyroid carcinoma (FVPTC) arising within a hyperfunctioning thyroid nodule. How to cite this article Shahbaz A, Fransawy Alkomos M, Mahendhar R, et al (July 20, 2018) Follicular Variant of Papillary Thyroid Carcinoma Presented as Autonomous Functioning Thyroid Nodule: A Case Report and Review of Literature. His TSH suppressed 0.29 uIU/mL (Reference range: 0.40–4.00 uIU/mL) while free thyroxine (FT4) 2.1 ng/dL (0.8–1.9 ng/dL) and free triiodothyronine (FT3) 4.2 pg/mL (1.5–4.1 pg/mL) elevated. On follow-up visit, radioactive iodine whole-body scan did not reveal any distant metastasis This case is a rare example of FVPTC arising within a toxic nodule
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