Follicular variant of papillary thyroid carcinoma in a Struma ovary: Report of a rare case

Abstract

Malignant struma ovarii is a very rare neoplasm and constitute 0.1-0.3% of all ovarian teratoma. Herein, we report a case of follicular variant of papillary carcinoma in a struma ovarii (SO) of left side in a young female of 21 years, presented with a tubo-ovarian (T-O) mass of diameter of 8 cm. Ultrasonography revealed, slightly bulky uterus and a large cystic T-O mass in left side. Total abdominal hysterectomy with left sided salpingo-oophorectomy was done. Histopathological examination revealed multiple thyroid follicles lined by cells having optically clear, overlapping nuclei with inconspicuous nucleoli. Some nuclei showed nuclear grooves also. No papillary structures were seen. Immunohistochemically, the tumor was positive for thyroid transcription factor (TTF). Both functionally and architecturally, thyroid gland was absolutely normal. Neither postoperative radiotherapy nor adjuvant chemotherapy was given, and the patient has remained disease free 6 months postoperatively.