Follicular fluid total antioxidant capacity in patient with PCOS

Abstract

The purpose of this study was to evaluate the association between the follicular fluid (FF) total antioxidant capacity (TAC) and in vitro fertilisation (IVF) outcomes in patients with PCOS (polycystic ovarian disease) and non-PCOS. Prospective crossectional study. A total of 61 consecutive women who had IVF were included in this study (22 woman with PCOS and 41 women with nonPCOS). Baseline parameters, clinical and laboratory outcomes and follicular fluid total antioxidant capacity on the day of oocyte retrieval were analysed and ART outcome was studied. Follicular fluid total antioxidant capacity showed no difference between PCOS and nonPCOS groups (p=0,27). There were no correlations between the FF total antioxidant capacity and follicle, oocyte, 2PN and embryo numbers in patients with PCOS and nonPCOS. Whereas there was a significant correlation with pregnancy and TAC levels in all patients (p=0,04). Higher FF TAC levels are associated with pregnancy after IVF. But there is no association between PCOS and TAC levels in FF. Furter study focusing on association between follicular fluid TAC and PCOS is needed.