Abstract
Infertility and reproductive problems have been reported in women with several neurological disorders, for example, demyelination. However, the physiology of such problems has remained unknown so far. The taiep rats are an animal neurological model that initially shows a hypomyelination followed by a progressive demyelination of the central nervous system. This animal has reproductive problems, and the aim of this work is to characterize the follicular development, secretion of ovarian hormones, and presence of noradrenaline in the ovaries of the female taiep rats in the juvenile and adult stages. The taiep rats have low body weight (approximately 19% less than that of SD rats), a delay of 4 days in the age of vaginal opening, and an irregularity in the estrous cycle by the absence or prolongation of some estral cycle stage. In the juvenile stage, we observed a decrease of approximately 44% in the total number of follicles with a 15% increase of atresia and an 80% decrease in the fluorescence intensity of catecholamines in the ovaries, with a 21% increment in plasma concentrations of testosterone. In the adult stage, we observed follicular cysts and a 50% decrease in fluorescence intensity of catecholamines in the ovaries, with changes in the secretion of ovarian hormones, an increase of 20 times in progesterone, and a decrement of a half in estradiol. The demyelination in taiep rats affects follicular development and steroidogenesis in the early stages of the animal's life, and this is maintained until adulthood.
Highlights
Infertility and reproductive problems have been reported in women with multiple sclerosis (MS), a demyelinating disease
We intend to contribute to knowledge about the ovarian level affectations that may be happening in an animal model of demyelinating disease
The body weight of taiep rats at the age of 30 days was 19% lower when compared to the body weight of Sprague–Dawley (SD) rats (77.2 ± 3 g of body weight vs. 99.2 ± 5.9 g of body weight, p < 0 05); this difference was preserved until the adult stage (Figure 2)
Summary
Infertility and reproductive problems have been reported in women with multiple sclerosis (MS), a demyelinating disease. MS is one of the most important demyelinating diseases. Reproductive problems have been reported in women with MS, ranging from sexual dissatisfaction and the absence of orgasms [3, 4], to menstrual irregularity and hormonal and ovarian follicular development alterations [5, 6]. The relationship between the presence of ovarian change and demyelinating disease has not been clearly stablished. It is well known that the functions of the ovary are regulated by gonadotropins secreted by the pituitary gland as a result of the stimulus from the hypothalamus by the gonadotropin-releasing hormone (GnRH). The ovary receives and sends nervous information via the superior ovarian
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