Abstract
The malignant lymphomas now known as Hodgkin’s disease were first described by Thomas Hodgkin in 1832. This disease is characterized by the presence of large, multinucleate cells, called Reed-Sternberg cells, which are scattered irregularly throughout Hodgkin’s infiltrates. Intermingled with the Reed-Sternberg cells is a mixed population of lymphocytes, histiocytes, eosinophils, plasma cells, and neutrophils. Histological subclassification of Hodgkin’s disease relies principally on variations in the proportions of lymphocytes and histiocytes. Thus, the lymphoma is subdivided into four types: lymphocyte predominant including the nodular paragranuloma, nodular sclerosis, mixed cellularity, and lymphocyte depleted (Lukes and Butler 1966). An estimated 4 new patients with Hodgkin’s disease per 100 000 population will be detected yearly. By chemotherapy and/or radiation approximately 75% of patients with Hodgkin’s disease can be cured.
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