Abstract
Tumours of the follicular dendritic cells are rare tumours. Therefore, information about adequate treatment and overall prognosis is limited. We report about a 55 year-old patient, who was operated because of a persisting cervical lymph node swelling. The histopathological investigation showed a predominantly fascicular, relatively cell-rich tumour. Immuno-phenotyping of this tumour confirmed the diagnosis of a follicular dendritic cell tumour. Crucial for the correct diagnosis was a positive immunoreaction for CD21 and CD68. Furthermore we could demonstrate positive immunostaining for Fas-ligand in this tumour similar to the immunophenotype of normal follicular dendritic cells. We conclude, that neoplastic lesions in cervical lymph nodes but also unclear tumours of other regions especially if they show fascicular growth patterns should be screened for a FDC tumour immunohistochemically. Immunoreactivity for Fas-ligand though not being specific could supplement the diagnostic decision process.
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