Abstract

Diffuse hyperplasia, which may occur in prechronic toxicity studies, has been grossly described as goiter (Latin gutter, throat). This is characterized by diffuse, uniform, bilateral enlargement of the thyroid gland; the weight of a hyperplastic gland may be ten times that of the normal thyroid gland. The diffusely hyperplastic thyroid gland is generally a darker red-brown color than the glands of control rats. This color difference has been attributed to increased vascularity and decreased follicular colloid in the hyperplastic gland. In short-term studies the capsular surface of the gland may be smooth but may become lobulated in studies of longer duration. The lobulated appearance has been attributed to the capsular fibrosis that may occur in more severe cases of hyperplasia.

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