Abstract
Follicle-stimulating hormone (FSH) plays a crucial role in human reproduction. Already, in the fetal and neonatal developmental stages, FSH activates the proliferation of the Sertoli cells and successively, in the pubertal phase, induces the mitotic activity of the spermatogonia and supports cellular differentiation to the round spermatid stage. This physiological role in spermatogenesis has induced various attempts to treat idiopathic oligozoospermic men with FSH. It is well known that treatment with gonadotrophins is very effective in subjects affected by hypogonadotropic hypogonadism, often leading to the restoration of normal spermatogenesis. The success of this treatment in these men has brought the utilization of the therapy with FSH in infertile oligozoospermic subjects, aimed at obtaining a quantitative increase in sperm count. However, the results obtained so far are still controversial. In this article, the literature is reviewed and the authors’ experience on using FSH treatment in oligozoospermic subjects is discussed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
