Follicle stimulating hormone (FSH) induction of aromatase and luteinizing hormone receptor (LHR) is dependent, in part, on the protein kinase a regulatory-rho-guanine nucleotide exchange factor AKAP13

Abstract

FSH drives ovarian folliculogenesis via protein kinase A (PKA). The PKA anchoring protein 13 (AKAP13) is highly expressed in the human ovarian follicle and is known to regulate PKA activation through binding of RII regulatory subunits. We previously reported that expression of AKAP13 was induced during follicular development in mice and humans1. Since FSH leads to activation of PKA, we sought to determine the role of AKAP13 in FSH receptor signaling in COV434, an FSH-responsive human granulosa cell line.