Folklore poly herbal extract: How is it implicated in the control of seizure susceptibility?

Abstract

Epilepsy is a chronic neurological disorder characterized by anenduring predisposition to generate seizures, may be associated with emotional and cognitive dysfunction. The study was to examine the antiepileptic potential of folklore polyherbal extract (PHE) which consists ofPterocarpus Santalinus, Mesua Ferrea. Linn. and Vetiveria zizanioides in experimental models of epilepsy using swiss albino mice. Ethanolic extract of three driedpowders taken from stamens of Mesua Ferrea. Linn. (MF), heart wood of Pterocarpus Santalinus (PS) and roots of Vetiveria zizanioides (VZ) were evaluated against Maximum Electroshock (MES) and Strychnine Induced Convulsions (SIC). The preliminary qualitative phytochemical analysis of PHE showed presence of alkaloids, flavonoids, steroids, saponins, triterpenoids and glycosides. The extract was subjected to behavioral parameters, anxiolytic, locomotor activity and motor co-ordination activity and also estimated biogenic amines in the brain. The PHE was showed anticonvulsant activity against MES-induced convulsion; tonic extension phase was abolished and offered a significant inhibition against SIC. PHE exhibited significantly increased the brain levels of serotonin, dopamine, noradrenaline and monoamine. PHE shows significant effect in behavioral activities at thedose of 500 mg/kg when compared to standard drug phenytoin (25mg/kg).The PHE contains flavones and saponins which may responsible for its CNS activity. The present study indicates the PHE possess the anti-epileptic activity by different mechanisms. Future studies are required to know the molecular mechanism of actions of PHE. Effect of Polyherbal extract on maximal electroshock induced seizures in miceTabled 1GroupsDuration of HLTE (sec)Quantal protection% protectionControl15.67±0.514/666.67Polyherbal extract14.33±0.81*5/683.33Phenytoin (25mg/kg)15.33±0.51*6/6100 Open table in a new tab