Abstract
The purpose of this study was to determine if folic acid supplementation improves endothelial vascular function (brachial artery flow-mediated dilation; FMD) in amenorrheic runners. Prospective cross-sectional study. Academic medical center in the Midwest. Ten amenorrheic and 10 eumenorrheic women runners from the community volunteered for this study. Each participant was treated with folic acid (10 mg/d) for 4 weeks. Brachial artery FMD was measured before and after folic acid supplementation with standard techniques. The brachial artery FMD response to reactive hyperemia improved after folic acid supplementation in amenorrheic women (3.0% +/- 2.3% vs. 7.7% +/- 4.5%; P = 0.02). In the eumenorrheic control group, there was no change in brachial artery FMD (6.7% +/- 2.0% vs. 5.9% +/- 2.6%; P = 0.52). This study demonstrates that brachial artery FMD, an indicator of vascular endothelial function, improves in amenorrheic female runners after short-term supplementation with folic acid.
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