Abstract

Researchers at the Division of Pediatric Neurology, Neurosciences Centre, New Delhi, India, performed a randomized, double-blind, placebo-controlled 6-month trial of oral folic acid supplement (0.5 mg/day) in children aged 6-15 years treated with phenytoin for epilepsy.

Highlights

  • The following clinical report supports the association of PC02 and outcome of HIE in neonates, but raises questions regarding a seizure as the measure of brain damage and disability

  • Kennedy Shriver NIH Neonatal Research Network report that infants exposed to low PC02 concentrations within the first 16 hours of life during whole body cooling were at increase risk of death/disability

  • Researchers at the Division of Pediatric Neurology, Neurosciences Centre, New Delhi, India, performed a randomized, double-blind, placebo-controlled 6-month trial of oral folic acid supplement (0.5 mg/day) in children aged 6-15 years treated with phenytoin for epilepsy

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Summary

Introduction

Researchers at the Division of Pediatric Neurology, Neurosciences Centre, New Delhi, India, performed a randomized, double-blind, placebo-controlled 6-month trial of oral folic acid supplement (0.5 mg/day) in children aged 6-15 years treated with phenytoin for epilepsy. Seizures induced by electroshock vary with strength of current and with age. A stronger current is required to induce a maximal tonic clonic seizure in rats older than 15-20 days.

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