Abstract
The PCN-224 with good optical properties have been successfully by using Zr as the metal node and 4,4,4,4-(Porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid) (TCPP) as the base ligand. Carrying Camptothecin (CPT) and doxorubicin (DOX), the material modified with folic acid (FA) forms a Drug@PCN-224-FA nanomaterial. The average particle size of Drug@PCN-224-FA was less than 200 nm, and it had high drug encapsulation efficiency for both CPT and DOX. At acidic conditions, the release rate of CPT is 46.42% and the release rate of DOX is 40.80%. In 630 nm laser irradiation, Drug@PCN-224-FA can efficiently produce reactive oxygen species (ROS) to kill cancer cells. In vitro cell experiments also show that Drug@PCN-224-FA has good biocompatibility and combined therapeutic effects.
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