Abstract
The assay of alkaline phosphatase (ALP) plays a key role in the diagnosis of various diseases. Herein, folic acid functionalized molybdenum oxide quantum dots (FA-MoOx QDs) are explored as fluorescence “turn- off and on” probes for assaying of Cu2+ ion and ALP, respectively. This fluorescence sensing strategy was based on the quenching of emission peak of FA-MoOx QDs at 445 nm by Cu2+ ion, followed by restoring of emission peak selectively with ALP. Based on the quenching and restoring of FA-MoOx QDs emission intensity, quantitative assay was developed for the detection of Cu2+ ion (0.20 – 500 µM) and ALP (0.06 – 150 U/L) with detection limits of 29 nM and 0.026 U/L, respectively. The developed FA-MoOx QDs-based fluorescence “turn- off and on” strategy exhibited satisfactory results for assaying of ALP in biofluids.
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