Abstract
Serum levels of folic acid activity and other hematological aspects were investigated in 46 patients with chronic liver disease, of whom 35 had alcoholic cirrhosis; 3, postnecrotic cirrhosis; and 8, hemochromatosis. Serum folic acid activity was definitely reduced in 7 patients, and borderline in 6. Nine of the 46 patients had megaloblastic or transitional-mega-loblastic erythropoiesis. Folic acid deficiency was usually present in these cases. In several patients, a combined deficiency of Vitamin B12 and folic acid was considered to exist. There was a correlation between reduced serum levels of folic acid activity and the presence of anemia, macrocytosis, megaloblastosis, an inadequate diet, and the excessive consumption of wines and spirits.
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