Abstract
To explore the association between folic acid deficiency and depression, the authors selected 48 patients and divided them into three groups–depressed patients, psychiatrically ill (but nondepressed) patients, and medically ill patients. All patients were hospitalized for one week and received standard diets with no drugs or vitamins. At the end of this time, depressed patients had significantly lower serum folic acid levels (P<.05) than did the patients in the other two groups, and patients with low serum folic acid levels obtained higher ratings on certain items of the Hamilton Rating Scale for depression. Folic acid deficiency depression may be a distinct entity.
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