Abstract
Development of advanced therapeutic modalities for the treatment of cancer are become a thirst area in the field of biomedical science now a day. Current therapeutic approaches to treat this fatal disease always refer to partial curability with unavoidable obstacles. Here, we have developed stearic-g-polyethyleneimine acid amphiphilic nanomicelle functionalized with folic acid-based carbon dots (CDs) for targeted anticancer drug (doxorubicin, DOX) delivery and concurrent bio-imaging for triple negative breast cancer (TNBC). Developed nanomicelle was characterized by FTIR, XRD, 1H NMR, fluorescence spectroscopy, TEM etc. Highest DOX release from the nanomicelle was observed at slightly acidic pH. It was also found that the nanomicelle can be successfully internalized by the MDA-MB-231 cells and able to inhibit cell proliferation. The IC50 value by free DOX against TNBC was around 10 μg/mL, whereas, DOX loaded CD functionalized stearic-g-polyethyleneimine (25 kDa) (DOX-CDSP-25) showed similar cytotoxicity on TNBC at the concentration of only 1.0 μg/mL, indicating the efficiency of the delivery system compared to that of free DOX. Scanning electron microscopy (SEM) analysis revealed the effect of DOX-CDSP-25 on MDA-MB-231 cellular morphology in 24 h. Along with, the fluorescence property offered by folic acid derived CD allowed CDSP-25 to be acted as a promising bio-imaging tool for TNBC.
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