Abstract
Abstract Targeted nano drug delivery systems can be considered as in vivo tiny physicians that can accurately detect the disease location and prescribe drugs at the same time. In some cases, these skilled doctors are equipped with diagnostic agents that can monitor the treatment process. These nano-robots are known as nanotheranostic agents. The aim of this study is to inset folic acid armed polymeric core–shell iron oxide nanoparticles as a new type of nanotheranostic agent. Here, iron oxide nanoparticles were synthesized by polyol method and coated with hyperbranched polyglycerol. Different in vitro tests (cell viability and hemocompatibility) were conducted on the nanoparticles to evaluate their biocompatibility. Then they were decorated with folic acid as targeting agents and examined with different in vitro test to detect the influence of targeting on cell uptake properties. Results represented that this new type of nano-robot with size around 11 nanometer was biocompatible and had a positive effect on cellular uptake of nanoparticles. Thus, these nanoparticles could be used as potentially useful nanotheranostic systems to defeat cancer cells with high folate expression.
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