Abstract
The human telomeric DNA sequence d[AGGG(TTAGGG)(3)] forms the G-quadruplex structure. The G-quadruplex structure has become an attractive target for the anticancer drugs, because it effectively inhibits telomerase activity. Recently, the human telomere G-quadruplex in K(+) solution has been determined as a hybrid of mixed parallel and antiparallel structures. In this study, we investigated the folding pathway of human telomeric hybrid G-quadruplex structure.
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