Abstract
The 1H NMR study of a CD mono-functionalized at its secondary face is presented. It is shown that mono-(3-Tyr-3-deoxy- altro)-β-CD undergoes a solvent-dependent conformational change. Passing from organic medium to water, a stable self-inclusion complex is formed. Such a folding is accompanied by a local structural modification of the substituted altrose ring, which can be easily detected from the important variation of its H1–H2 coupling constant.
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