Abstract
In a number of recent studies a tight interconnection between the spatial organization of the eukaryotic genome and itsfunctioning hasbeen demonstrated. Moreover, itisbecoming evidentthatthefolded DNA byitselfconstitutes an important, if not the key, factor supporting the internal nuclear organization. In this review, we will discuss the current state of chromatin research with the special attention focused on chromosome territories, chromatin folding and dynamics, chromatin domains, transcription and replication factories. Based on this analysis we will show how interphase chromosomes define the assembly of different nuclear compartments and underlie the spatial compartmentalization of the cell nucleus.
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