Abstract
The increase of microarray experiments brings a fresh challenge to analyze microarray data across datasets. Several methods have been developed and implemented. But the current tools were either complicated software with inefficiency methods or web applications, among which some were limited to specific data format. In this paper, we propose Fold-based Meta-analysis (FM), a method to identify Differentially Expressed Genes (DEGs) in microarray data. It could meta-analyze datasets in either the same or different platforms. We test FMT, respectively, on two published Arabidopsis datasets in one platform and three Mouse datasets in three different platforms, and then analyze the Gene Ontology (GO) terms or metabolic pathways of the most DEGs. Our results show that they are highly agreed on DEGs, and many of them are crucial and functional. In summary, our method is fast and practical.
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