Abstract
In recent years, a great deal of new information on the identity and distribution of the naturally occurring folates, on the adult daily requirement for folic acid, and on folate‐vitamin B12 interrelationships has been published. The compound, 5‐methyltetrahydrofolate, has been found rfo be present in significant amounts in human serum, red cells, and liver, and to be involved in the synthesis of methionine from homocysteine, a reaction which appears to require vitamin B12. In vitamin B12,‐deficiency states, such as pernicious anemia, 5‐methyltetrahydrofolate cannot be demethylated to yield rtetrahydrofolate, and as a consequence a secondary defiCiency of tetrahydrofolate develops. These and other recent studies concerning folates and the megaloblastic anemias are re1Jiewed.
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