Abstract
Folate receptors (FR) are up-regulated in a variety of epithelium-derived and non epitheli-um- derived human cancers, and the expression is greatly higher than that in normal cells and has tissue specific-ity. FR is an important way for cells' uptake of foLate. Its mechanism is endocytosis mediated by receptors,and this mechanism has high affinity, high specificity and good potential to transport substances. Many studies show that FR-expressing cancer tissues can be detected by combining specifically targeted diagnosis agents such as radionuclide linked with folate,fluorescein and MRI contrast agents with FR,there is no such effect in normal tissues. This indicates the feasibility and application prospect of FR-targeted tumor diagnosis strategies. Key words: Folate receptor; Neoplasms; Molecular biology; Diagnostic imaging
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